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Clinical Chemistry 10: 53-61, 1964;
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Clinical Chemistry, Vol 10, 53-61, Copyright © 1964 by the American Association for Clinical Chemistry

The Oxidation of Glutathione by Serum

Hugo R. Rony 1, Michael West 1, and Hyman J. Zimmerman 1

1 Department of Medicine of The Chicago Medical School and Mount Sinai Hospital, Chicago 8, Ill.

Studies of serum glutathione reductase activity in this laboratory prompted an attempt to demonstrate glutathione oxidase in the serum. The oxidation of reduced glutathione in the sera of patients with various diseases does not differ from normal sera. Preheating the serum and addition of cytochrome c does not effect the oxidizing capacity of the serum. The ability of serum to oxidize reduced glutathione appears to represent autoxidation, not the effect of an oxidizing enzyme.

Submitted on October 6, 1961






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Copyright © 1964 by the American Association for Clinical Chemistry.