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Clinical Chemistry 10: 1059-1065, 1964;
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Clinical Chemistry, Vol 10, 1059-1065, Copyright © 1964 by the American Association for Clinical Chemistry

Urea Synthesis by Hemic Cells

W. Tabb Moore 1, Joseph Rodarte 1, and Lloyd H Smith Jr 2

1 Department of Medicine, Harvard Medical School, and the Massachusetts General Hospital, Boston, Massachusetts.
2 Department of Medicine, University of California School of Medicine, San Francisco, Calif.

A method for measuring urea production by isolated erythrocytes and leucocytes under physiologic conditions is described. Erythrocytes from 10 normal subjects formed an average of 82.5 mµmoles urea/ml. packed cells/hr. Leucocytes formed 7.4 mµmoles urea/108 cells/hr. By extrapolation, total urea synthesis by circulating erythrocytes would be approximately 270 mg./day and by the granulocyte pool approximately 5 mg./day. The total contribution of circulating hemic cells to over-all urea synthesis approximates 1 to 3% on an average protein diet. Six patients with cystinuria were also studied. No defect in urea synthesis, as a reflection of impaired arginine transport, could be detected in their blood cells with the conditions employed.

Submitted on October 28, 1963




The following articles in journals at HighWire Press have cited this article:


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 J. Nutr.Home page
S. M. Morris Jr.
Arginine Metabolism: Boundaries of Our Knowledge
J. Nutr., June 1, 2007; 137(6): 1602S - 1609S.
[Abstract] [Full Text] [PDF]


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Copyright © 1964 by the American Association for Clinical Chemistry.