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Clinical Chemistry 10: 184-187, 1964;
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Clinical Chemistry, Vol 10, 184-187, Copyright © 1964 by the American Association for Clinical Chemistry

Comparison of Enzyme Activities of Arterial Samples from Sexually Mature Men and Women

John Esben Kirk 1

1 Washington University School of Medicine, St. Louis, Mo.

A comparison was made of activities of 25 different enzymes in aortic, pulmonary artery, and coronary artery samples derived from 18- to 54-year-old men and women. The aorta and coronary artery of women were found to contain lower concentrations of 4 TPN-dependent enzymes (glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, isocitric dehydrogenase, and TPN-malic enzyme). Since TPNH is a compound involved in the synthesis of cholesterol and fatty acids, the observed sex difference in arterial TPN-dependent enzyme activities may be associated with the lower susceptibility of premenopausal women to arteriosclerosis.

Submitted on April 20, 1963






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Copyright © 1964 by the American Association for Clinical Chemistry.