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Clinical Chemistry 10: 589-596, 1964;
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Clinical Chemistry, Vol 10, 589-596, Copyright © 1964 by the American Association for Clinical Chemistry

Distribution of Ammonia in Cells and Plasma

F. L. Humoller 1, A. J. Barak 1, and J. M. Holthaus 1

1 Medical Research Laboratory and the Medical Service, Veterans Administration Hospital, Omaha, Neb.

A method for the determination of plasma and whole blood ammonia is outlined which incorporates the desirable features of several older methods. By means of this method it has been demonstrated that the distribution of ammonia in erythrocytes and plasma of normal individuals is nearly equal to that of hydrogen ions. The ratio remains constant in cirrhosis, alkalemia, and ammonemia. It was observed in 82 consecutive admissions of cirrhotic patients that alkalemia was present in only a small percentage of the cases.

Submitted on June 25, 1963






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Copyright © 1964 by the American Association for Clinical Chemistry.