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Clinical Chemistry 10: 611-618, 1964;
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Clinical Chemistry, Vol 10, 611-618, Copyright © 1964 by the American Association for Clinical Chemistry

Decolorization on Freezing of Ferricyanide-Cyanide Solution used for Hemoglobin Determinations

Olaf Mickelsen 1, Helen Woolard 2, and Arthur T. Ness 3

1 Department of Foods and Nutrition, Michigan State University, East Lansing, Mich.
2 Office of Extramural Program, National Institutes of Arthritis and Metabolic Diseases, Bethesda, Md.
3 Laboratory of Nutrition and Endocrinology, NIAMD, and Laboratory of Clinical Pathology, Clinical Center, National Institutes of Health, Bethesda, Md.

When Drabkin's solution (used for the determination of hemoglobin), which contains K3Fe(CN)6, KCN, and NaHCO3, is frozen, it loses its greenish-yellow color. The solution remains colorless even after thawing. The reaction, for which there is no satisfactory explanation, involves the reduction of the K3Fe(CN)6 to K4Fe(CN)6, with KCN being oxidized to KCNO.

Submitted on May 2, 1969






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Copyright © 1964 by the American Association for Clinical Chemistry.