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Clinical Chemistry 11: 925-931, 1965;
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Clinical Chemistry, Vol 11, 925-931, Copyright © 1965 by the American Association for Clinical Chemistry

A New Method for the Determination of Nitrofurantoin in Urine

John D. Conklin 1 and Richard D. Hollifield 1

1 Biological Research Division, The Norwich Pharmacal Co., Norwich, N. Y. 13815.

Nitrofurantoin is presently used as an antibacterial agent for the urinary tract of both man and animals. A new, quantitative procedure for the determination of this drug in urine consists of direct extraction of the nonionized form of the drug by the use of nitromethane, addition of an alkaline reagent to the extract to produce a visible color, and determination of the nitrofurantoin concentration by spectrophotometry. The method has a sensitivity of 5 mg./L., with recoveries of 99-101% and a standard curve that is linear to 100 mg./L. Results indicate that the method measures nitrofurantoin alone, and not its metabolites, in rat, dog, and human urine.

Submitted on March 18, 1965
Accepted on July 13, 1965






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Copyright © 1965 by the American Association for Clinical Chemistry.