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Clinical Chemistry 11: 1019-1022, 1965;
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Clinical Chemistry, Vol 11, 1019-1022, Copyright © 1965 by the American Association for Clinical Chemistry

The Effect of Methenamine Mandelate (Mandelamine) on Determination of Urinary Estriol

Joseph C. Touchstone 1, Maria Stojkewycz 1, and Kaighn Smith 1

1 Department of Obstetrics and Gynecology, School of Medicine, University of Pennsylvania, Philadelphia, Pa. 19104.

The administration of methenamine mandelate (Mandelamine) to pregnant women causes the levels of estriol in their urines to be unmeasurably low when acid hydrolysis is used. When enzyme hydrolysis replaces acid hydrolysis, normal estriol values are obtained. This result is attributed to the formaldehyde released by acid from hexamethylenetetramine, a constituent of the drug. The formaldehyde reacts with estriol to prevent its determination.

Submitted on June 1, 1965
Accepted on August 9, 1965




The following articles in journals at HighWire Press have cited this article:


Home page
 Clin. Chem.Home page
H. W.M. van Laarhoven, J. J. Willemsen, H. A. Ross, L. V.A.M. Beex, J. W.M. Lenders, and F. C.G.J. Sweep
Pitfall in HPLC Assay for Urinary Metanephrines: An Unusual Type of Interference Caused by Methenamine Intake
Clin. Chem., June 1, 2004; 50(6): 1097 - 1099.
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Copyright © 1965 by the American Association for Clinical Chemistry.