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Clinical Chemistry 11: 1045-1050, 1965;
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Clinical Chemistry, Vol 11, 1045-1050, Copyright © 1965 by the American Association for Clinical Chemistry

An Automated Method for the Determination of Sulfonamides in Plasma

H. B. Falk 1 and R. G. Kelly 1

1 Department of Pharmacological Research, Lederle Laboratories, American Cyanamid Company, Pearl River, N. Y. 10965.

An automated adaptation of the Bratton-Marshall procedure for sulfonamides has been developed. As sulfonamides exhibit varying degrees of protein binding, application of the method to plasma is dependent upon release of these compounds prior to automated dialysis. This release is effected by the acidification of the sample. The results obtained with and without this preliminary acidification are discussed.

Submitted on March 9, 1965
Accepted on September 7, 1965






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Copyright © 1965 by the American Association for Clinical Chemistry.