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Clinical Chemistry 11: 570-574, 1965;
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Clinical Chemistry, Vol 11, 570-574, Copyright © 1965 by the American Association for Clinical Chemistry

On the Nature of the Inhibitor of Urinary Alkaline Phosphatase

Stephen D. Hilliard 1, James F. O'Donnell 2, and Steven Schenker 2

1 Gastrie Laboratory, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229.
2 Gastric Laboratory, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229.

The inhibition of urinary alkaline phosphatase has been shown to be caused principally by the inorganic phosphates which are naturally excreted in urine. An inorganic phosphate concentration of 15 mg./100 ml. resulted in approximately 50% inhibition, and that of 120 mg./100 ml. in an inhibition of about 90%. Evidence is presented which shows that the inhibition is of the competitive type.

Submitted on October 29, 1964
Accepted on January 7, 1965




The following articles in journals at HighWire Press have cited this article:


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J. Clin. Endocrinol. Metab.Home page
S. P. Coburn, J. D. Mahuren, M. Jain, Y. Zubovic, and J. Wortsman
Alkaline Phosphatase (EC 3.1.3.1) in Serum Is Inhibited by Physiological Concentrations of Inorganic Phosphate
J. Clin. Endocrinol. Metab., November 1, 1998; 83(11): 3951 - 3957.
[Abstract] [Full Text]




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Copyright © 1965 by the American Association for Clinical Chemistry.