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Clinical Chemistry 11: 575-580, 1965;
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Clinical Chemistry, Vol 11, 575-580, Copyright © 1965 by the American Association for Clinical Chemistry

A Pituitary Gonadotropin Assay Based on Absorption by Attapulgite

William B. Watson 1 and R. William Knouse 2

1 Hoffman-LaRoche Inc., Nutley, N. J.
2 Linden Associates Laboratory, 28 Eighth St., Atlanta, Ga. 30302.

A method for extraction of pituitary gonadotropins utilizing attapulgite and acetone is presented and compared with the kaolin-acetone (Edinburg) method. The attapulgite-acetone extracts contained less inert material and were less toxic. The results of over 100 consecutive clinical assays are presented and analyzed.

Submitted on November 16, 1964
Accepted on January 11, 1965






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Copyright © 1965 by the American Association for Clinical Chemistry.