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Clinical Chemistry 11: 645-652, 1965;
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Clinical Chemistry, Vol 11, 645-652, Copyright © 1965 by the American Association for Clinical Chemistry

Procedure for Detecting Atypical Serum Cholinesterase Using o-Nitrophenylbutyrate as Substrate

R. B. McComb 1, R. V. LaMotta 2, and H. J. Wetstone 2

1 Department of Pathology, Hartford Hospital.
2 Research Laboratories, Department of Medicine, Hartford Hospital, Hartford, Conn. 06115.

A method has been developed for demonstrating atypical serum cholinesterase by means of the self-indicating substrate, o-nitrophenylbutyrate and the inhibitor succinyldicholine. The procedure was tested for atypical cholinesterase with 76 individuals, including 5 otherwise proven homozygotes and their immediate families. In all cases, it was possible to distinguish clearly those individuals homozygous for the usual and atypical cholinesterase as well as heterozygotes.

Submitted on December 15, 1964
Accepted on February 17, 1965






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Copyright © 1965 by the American Association for Clinical Chemistry.