Clinical Chemistry
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Clinical Chemistry 11: 653-663, 1965;
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Clinical Chemistry, Vol 11, 653-663, Copyright © 1965 by the American Association for Clinical Chemistry

The Clinical Stability of Serum Cholinesterase Activity

Howard J. Wetstone 1 and Rudolph V. LaMotta 1

1 Department of Medicine Research Laboratories, Hartford Hospital, Hartford, Conn. 06115.

Intra-individual variation of serum cholinesterase activity as determined in 82 normal adults studied 373 times over periods up to 5 years is found to be relatively low. The over-all coefficient of variation was 8.4, the linear correlation between the first and subsequent tests in the same person was r = .87 (first versus second test in 82 subjects) and r = .90 (first versus seventh test in 14 people). A decline of 0.66 U. from a single prior measurement when in normal health is significant at the .05 level. The clinical significance of the test is discussed.

Submitted on December 30, 1964
Accepted on February 24, 1965






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Copyright © 1965 by the American Association for Clinical Chemistry.