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Clinical Chemistry 12: 789-796, 1966;
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Clinical Chemistry, Vol 12, 789-796, Copyright © 1966 by the American Association for Clinical Chemistry

Amobarbital Metabolism in Man

A Gas Chromatographic Method for the Estimation of Hydroxyamobarbital in Human Urine

Jerome J. Kamm 1 and Edward J. Van Loon 1

1 Smith Kline & French Laboratories, 1500 Spring Garden St., Philadelphia, Pa. 19101.

A gas chromatographic method for the estimation of microgram quantities of hydroxy-amobarbital in urine is described. The method has been applied to a study of the metabolic fate of therapeutic doses of amobarbital (60 and 180 mg.) in man. We have found that 45% of an ingested dose of the drug is excreted in urine as hydroxy-amobarbital in 3 days and that small amounts of the metabolite are detectable for as long as 5 days following the ingestion of a single 180-mg. dose of amobarbital.

Submitted on June 16, 1966
Accepted on July 7, 1966






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Copyright © 1966 by the American Association for Clinical Chemistry.