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Clinical Chemistry 12: 206-210, 1966;
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Clinical Chemistry, Vol 12, 206-210, Copyright © 1966 by the American Association for Clinical Chemistry

Solubility Determination of Cholesterol Polymorphs in Organic Solvents

Royce D. Stauffer 1 and Fritz Bischoff 1

1 Chemical Laboratory, Santa Barbara Cottage Hospital Research Institute, Santa Barbara, Calif. 93105.

In a study of the solubility of crystalline forms of cholesterol in various solvents, the solubilities (per cent by weight) of cholesterol needles and hydrated plates at 38° were, respectively, 4.0 and 3.2% in olive oil; 2.6 and 1.9% in tetradecane; 26.2 and 9% in toluene; and 21.0 and 7% in cyclohexane. When these solvents are in equilibrium with an aqueous phase, needles are converted to plates. Pseudomorph ( dehydrated) plates in olive oil have the solubility of needles. These differences may have significance in studies involving cholesterol pathogenesis.

The modified Zak reaction with ethanol could not be used for the assay of cholesterol in olive oil since the reaction product was turbid. Higher alcohols were studied as a substitute for ethanol; 2-propanol was satisfactory.

Submitted on October 22, 1965
Accepted on January 5, 1966




The following articles in journals at HighWire Press have cited this article:


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D. Mufson, K. Meksuwan, J. E. Zarembo, and L. J. Ravin
Cholesterol Solubility in Lecithin-Bile Salt Systems
Science, August 25, 1972; 177(4050): 701 - 701.
[Abstract] [PDF]


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Copyright © 1966 by the American Association for Clinical Chemistry.