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Clinical Chemistry 12: 577-585, 1966;
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Clinical Chemistry, Vol 12, 577-585, Copyright © 1966 by the American Association for Clinical Chemistry

Urinary Chorionic Gonadotrophin Determination

Derek Watson 1

1 Department of Laboratories, Royal Columbian Hospital, New Westminster, British Columbia, Canada.

Successful laboratory tests for early pregnancy utilize the endogenous production and excretion of chorionic gonadotrophin (CG). There is wide variation in sensitivity and specificity of various biological and commercially available immunochemical methods for determining urinary CG levels. Normal values for immunochemically reactive CG during the first trimester of pregnancy are given.

Serial determinations of CG have diagnostic value in assessing various abnormal pregnancy states. An abnormally increased urinary output of CG is observed in some neoplasms—e.g., chorionepithelioma, and a rapidly rising CG level is strongly suggestive of molar pregnancy. Urinary CG levels falling below the normal range mayindicate an ectopic pregnancy or an inevitable, incomplete, or "missed" abortion.

The immunochemical CG determination also offers a sensitive, simple, and convenient routine method for following patients who have been treated for hydatidiformmole or chorionepithelioma.

Submitted on January 11, 1966
Accepted on May 19, 1966






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Copyright © 1966 by the American Association for Clinical Chemistry.