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Clinical Chemistry 12: 586-591, 1966;
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Clinical Chemistry, Vol 12, 586-591, Copyright © 1966 by the American Association for Clinical Chemistry

Studies of Some Indole Compounds Isolated from the Urine of a Mentally Retarded Child

J. Fischl 1 and S. Israel 1

1 Department of Biochemistry, "Asaf Harofe" Government Hospital, Zerifin, Israel.

During the investigation of the urine of a mentally retarded child, a number of indole compounds were isolated. Gel filtration of the native urine gave three chief fractions. phatase fraction of blood had properties unlike that of the red blood cell enzyme and

Extraction methods available for the isolation of the abnormal indoles in large amounts resulted in irreversible structural changes, probably detachment of the carboxy groups, with loss of electrophoretic mobility, changes of chromatographic properties, and decreased water solubility.

It is presumed that the presence of the abnormal indoles isolated is the result of disturbed metabolism of the aromatic amino acids.

Submitted on November 3, 1965
Accepted on May 25, 1966






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Copyright © 1966 by the American Association for Clinical Chemistry.