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Clinical Chemistry 12: 592-595, 1966;
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Clinical Chemistry, Vol 12, 592-595, Copyright © 1966 by the American Association for Clinical Chemistry

Screening Test for Hydrindicuria

J. Fischl 1 and S. Israel 1

1 Department of Biochemistry, "Asaf Harofe" Government Hospital, Zerifin, Israel.

A screening test is described for the detection of a type of disorder associated with the metabolism of melanin and manifested by mental symptoms. The test employs the conversion of the urinary melanogens to hydrindic acid by acidification. By extracting the pigment with iso-butanol and purifying the extract by washing, the urinary excretion levels may be assayed by photometry.

Submitted on November 3, 1965
Accepted on May 25, 1966






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Copyright © 1966 by the American Association for Clinical Chemistry.