Clinical Chemistry
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Clinical Chemistry 13: 12-18, 1967;
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Clinical Chemistry, Vol 13, 12-18, Copyright © 1967 by the American Association for Clinical Chemistry

Determination of Uric Acid

An Adaptation of the Archibald Method on the AutoAnalyzer

H. Harold Nishi 1

1 Clinical Chemistry Service, Clinical Pathology Department, Clinical Center, National Institutes of Health, Bethesda, Md. 20014.

The Archibald colorimetric procedure for determination of uric acid has been adapted for automation. The major differences from the original manual procedure after sodium hydroxide treatment of the serum sample are neutralization with hydrochloric acid and dialysis of the serum instead of precipitation to remove protein. At the rate of 40 samples per hour, the automated procedure shows good correlation with the manual procedure.

Submitted on March 24, 1966
Accepted on August 3, 1966




The following articles in journals at HighWire Press have cited this article:


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 Arch Intern MedHome page
H. G. Langford, M. D. Blaufox, N. O. Borhani, J. D. Curb, A. Molteni, K. A. Schneider, and S. Pressel
Is Thiazide-Produced Uric Acid Elevation Harmful? Analysis of Data From the Hypertension Detection and Follow-up Program
Arch Intern Med, April 1, 1987; 147(4): 645 - 649.
[Abstract] [PDF]


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Copyright © 1967 by the American Association for Clinical Chemistry.