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Clinical Chemistry 13: 1026-1028, 1967;
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Clinical Chemistry, Vol 13, 1026-1028, Copyright © 1967 by the American Association for Clinical Chemistry

Fibrinogen Assay

William R. Swaim 1 and Marija B. Feders 1

1 Research and Medical Services, Veterans Administration Hospital, Minneapolis, and the Department of Medicine, University of Minnesota, Minneapolis, Minn. 55417.

Precise, reproducible quantitation of fibrinogen from plasma using thrombin to convert it to fibrin requires careful attention to the technics of clot formation and syneresis. The precision of the method outlined indicates a coefficient of variation of 1.2% with replicate samples. The coefficient of variation in sequential studies of a single purified bovine fibrinogen pool was 2.8% and for a lyophilized commercial plasma it was 4.7%.

Submitted on April 25, 1967
Accepted on May 29, 1967




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Copyright © 1967 by the American Association for Clinical Chemistry.