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Clinical Chemistry 13: 917-930, 1967;
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Clinical Chemistry, Vol 13, 917-930, Copyright © 1967 by the American Association for Clinical Chemistry

Applications of Computer Produced Frequency Distribution Curves

I. Quality Control

N. Ressler 1 and L. S. Whitlock 1

1 Departments of Pathology and of Biological Chemistry, The University of Michigan Medical School, and from the Department of Biostatistics, The University of Michigan School of Public Health, Ann Arbor, Mich.

Applications to quality control of a laboratory's own individual frequency distribution curves are described. The method has recently become feasible for routine use, since the curves can now be compiled automatically by means of an electronic data-processing system. Applications described include verification of the validity of results generated by a given method in terms of the frequency distributions obtained for each type of diagnostic classification, and the determination of the constancy of these distributions. The relative value of different test methods can be compared by the success which is achieved in distinguishing diagnostic classifications (as measured by the overlaps of different frequency distribution curves). Individual frequency distributions can also be used to determine the precision required for given test, in order to avoid any loss in the discrimination which can be achieved.

Submitted on December 6, 1966
Accepted on May 10, 1967






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Copyright © 1967 by the American Association for Clinical Chemistry.