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Clinical Chemistry 13: 196-203, 1967;
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Clinical Chemistry, Vol 13, 196-203, Copyright © 1967 by the American Association for Clinical Chemistry

Lactate Dehydrogenase Isoenzymes

A Comparison of Pyruvate-to-Lactate and Lactate-to-Pyruvate Assays

Arthur F. Krieg 1, Lawrence J. Rosenblum 1, and John B. Henry 1

1 Department of Pathology, State University of New York, Upstate Medical Center, 750 East Adams St., Syracuse, N. Y. 13210.

Five lactate dehydrogenase isoenzymes are normally observed in human serum: H4 (LDH1), H3M (LDH2), H2M2 (LDH3), HM3 (LDH4), and M4 (LDH5). This study presents evidence that these isoenzymes vary in the ratio of LDH activity (pyruvate rarr lactate) to LDH activity (lactate rarr pyruvate).

Submitted on July 5, 1966
Accepted on October 10, 1966






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Copyright © 1967 by the American Association for Clinical Chemistry.