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Clinical Chemistry 13: 242-254, 1967;
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Clinical Chemistry, Vol 13, 242-254, Copyright © 1967 by the American Association for Clinical Chemistry

Estimation of the Antitrypsin Activity of Serum

Albert A. Dietz 1, LaVerne K. Hodges 1, Herbert M. Rubinstein 1, and Robert R. Briney 1

1 Research and Medical Services, Veterans Administration Hospital, Hines, III. 60141.

A method for the estimation of serum trypsin inhibitory capacity (TIC) was developed to permit consistent results with various trypsin sources without further standardization. Very small volumes of serum are used and the results are expressed in international enzyme units. Normal women show a slightly higher mean value for TIC than normal men. Sixty-seven patients with pulmonary emphysema were surveyed: one patient homozygous for alpha1-antitrypsin deficiency was found.

Submitted on August 9, 1966
Accepted on November 16, 1966






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Copyright © 1967 by the American Association for Clinical Chemistry.