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Clinical Chemistry 13: 626-649, 1967;
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Clinical Chemistry, Vol 13, 626-649, Copyright © 1967 by the American Association for Clinical Chemistry

Sulfur Content of Paper Electrophoretic Fractions In Human Serum

Samuel Natelson 1 and Rodney Stellate 1

1 Department of Biochemistry, Michael Reese Hospital and Medical Center, Chicago, Ill. 60616.

Instrumentation is described for scanning paper electrophoretic strips for the sulfur distribution of the fractionated serum proteins with the vacuum X-ray spectrometer. Paper electrophoretic patterns of serum proteins scanned by X-ray spectrometry for sulfur content of the various fractions and by protein staining are compared.

For 26 blood donors, the mean percentages of sulfur found in the different fractions were: albumin, 1.64; and globulins: alpha1, 0.63; alpha2, 1.10; beta, 1.14; and gamma, 0.98. The procedure was then applied to the serum of patients with diseases of the liver and of the kidney, various types of malignancies, and other diseases.

The percentage of sulfur in abnormal fractions varies widely. This permits, in some cases, detection of abnormal peaks which would otherwise be missed by protein staining alone.

This technic should be of value in the identification and classification of abnormal protein fractions, when combined with studies by the ultracentrifuge and immuno-electrophoresis.

Submitted on November 28, 1966
Accepted on January 2, 1967






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Copyright © 1967 by the American Association for Clinical Chemistry.