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Clinical Chemistry 13: 734-743, 1967;
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Clinical Chemistry, Vol 13, 734-743, Copyright © 1967 by the American Association for Clinical Chemistry

Method for the Determination of Acetylsalicylic Acid in the Blood

J. I. Routh 1, N. A. Shane 1, E. G. Arredondo 1, and W. D. Paul 1

1 Departments of Biochemistry, and Physical Medicine and Rehabilitation, University of Iowa, Iowa City, Iowa 52240, and Bristol-Myers Products Division, Hillside, N. J.

The shift in the UV spectral absorption curves of acetylsalicylic acid (ASA) and salicylic acid (SA) produced by a change in pH has been used in the development of a method for the quantitation of these compounds. The differential spectral absorption curve of ASA exhibits a maximum at 300 mµ, while that of SA shows a maximum at 319 mµ and an isosbestic point at 300 mµ. The method is simple and specific for ASA and capable of determining the concentration of the ASA and SA in the blood after the ingestion of 10 gr. of aspirin.

Submitted on October 28, 1966
Accepted on January 23, 1967






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Copyright © 1967 by the American Association for Clinical Chemistry.