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Clinical Chemistry 13: 760-768, 1967;
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Clinical Chemistry, Vol 13, 760-768, Copyright © 1967 by the American Association for Clinical Chemistry

Calcium Determinations in Kinetic Studies

II. Blood- and Urine-Specific Activity Determinations

Joan Harrison 1, A. J. W. Hitchman 1, and J. M. Finlay 1

1 Department of Medicine, University of Toronto, Toronto 5, and Gastroenterology Laboratory, Toronto General Hospital, 101 College Street, Toronto 2, Ontario, Canada.

Published reports of a fraction of blood calcium that does not equilibrate with a tracer has created a controversy that challenges the validity of much calcium kinetic data. To resolve this controversy, calcium specific-activity measurements were made on blood and urine samples in vitro and in vivo. The experiments were designed to provide maximal sensitivity for demonstrating non exchangeable calcium. A new and accurate method for urine calcium determinations was used. The results demonstrated complete equilibration between tracer and stable blood calcium. We suggest that published evidence of non exchangeable calcium in blood and urine is erroneous due to inaccurate urine calcium determinations.

Submitted on January 7, 1967
Accepted on February 17, 1967






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Copyright © 1967 by the American Association for Clinical Chemistry.