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Clinical Chemistry 14: 944-959, 1968;
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Clinical Chemistry, Vol 14, 944-959, Copyright © 1968 by the American Association for Clinical Chemistry

Regulation of Plasma Creatinine Concentration by Use of a Servo Control System

Rodney B. Harvey 1, James B. Bassingthwaighte 1, and Richard L. Heppner 1

1 University of Minnesota, Minneapolis, Minn., and Mayo Clinic, Rochester, Minn. 55901.

A method for controlling the plasma creatinine concentration is described. This method uses continuous determination of the plasma creatinine concentration and a servomechanism which drives an infusion pump at a rate proportional to the difference between the actual and desired creatinine concentrations. The rate and volume of creatinine infusion necessary to maintain the desired plasma concentration provide information related to kidney function and the accumulation of creatinine in the body. Experiments using this technic and the method of data analysis are described. It has been shown that under certain conditions this technic may be used to estimate the renal clearance of creatinine and the size and nature of the space into which creatinine is distributed in the dog.

Submitted on December 27, 1967
Accepted on February 5, 1968






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Copyright © 1968 by the American Association for Clinical Chemistry.