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Clinical Chemistry 14: 967-978, 1968;
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Clinical Chemistry, Vol 14, 967-978, Copyright © 1968 by the American Association for Clinical Chemistry

A Study of 2,4,6-Trinitrobenzenesulfonic Acid for Automated Amino Acid Chromatography

Harold H. Brown 1

1 Harrisburg Polyclinic Hospital, Third and Radnor Streets, Harrisburg, Pa. 17105.

The reaction of 2,4,6-trinitrobenzenesulfonic acid (TNBS) with amino acids was investigated by a static system to develop optimum conditions for application to automated amino acid chromatography. TNBS was found to be a very simple and sensitive reagent, easier to use than ninhydrin. The reaction occurs quite rapidly at room temperature, eliminating the requirement of a heating bath. The major disadvantage is a much lower sensitivity to the imino acid proline than to the amino acids.

Submitted on November 13, 1967
Accepted on February 5, 1968






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Copyright © 1968 by the American Association for Clinical Chemistry.