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Clinical Chemistry 14: 212-221, 1968;
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Clinical Chemistry, Vol 14, 212-221, Copyright © 1968 by the American Association for Clinical Chemistry

One-Dimensional Paper Chromatographic Method for Determination of Urinary Homovanillic Acid

Phillip S. Duke 1 and Harry B. Demopoulos 1

1 Department of Pathology, School of Medicine, University of Southern California, Los Angeles, Calif.

A one-dimensional paper chromatographic method is presented for determination of urinary homovanillic acid. The method is faster and gives higher values than does two-dimensional chromatography. Urinary homovanillic acid values are given for patients with metastatic malignant melanoma and for presumed normals. Homovanillic acid level was elevated in the case of amelanotic melanoma. Determinations of urinary homovanillic acid may be a valuable adjunct to the therapy and study of metastatic malignant melanoma.

Submitted on May 8, 1967
Accepted on June 20, 1967






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Copyright © 1968 by the American Association for Clinical Chemistry.