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Clinical Chemistry 14: 360-367, 1968;
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Clinical Chemistry, Vol 14, 360-367, Copyright © 1968 by the American Association for Clinical Chemistry

Determination of Serum Albumin

J. W. Keyser 1

1 Department of Clinical Chemistry, The Welsh National School of Medicine, University of Wales, The Royal Infirmary, Cardiff, United Kingdom.

Good agreement was obtained between an electrophoretic and an immunoprecipitation method for serum albumin, and it is suggested that these offer a means of determining serum albumin concentration with reasonable accuracy. The methyl orange dye-binding method tends to give slightly higher results in disease and occasionally larger discrepancies as compared with the electrophoretic and immunoprecipitation methods, but results are little affected, if at all, by the presence of large amounts of paraproteins. The dye-binding method appears to be ideal for population surveys.






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Copyright © 1968 by the American Association for Clinical Chemistry.