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Clinical Chemistry 14: 371-373, 1968;
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Clinical Chemistry, Vol 14, 371-373, Copyright © 1968 by the American Association for Clinical Chemistry

Rapid Detection of Organic Phosphorus Poisons

J. Fischl 1, N. Pinto 1, and C. Gordon 1

1 Department of Biochemistry, "Asaf Harofe" Government Hospital, Zerifin, and the Central Laboratories of the Sick Fund for National Workers. Tel-Aviv P.O.B. 2209, Israel.

Strips of filter paper are impregnated with a buffered acetylcholine substrate solution, containing phenol red as an indicator, and 1,2-propyleneglycol serving as an inhibitor of bacterial decomposition and as a wetting agent. The test is suitable for the detection of the poison in vivo, as well as in suspected materials such as food, clothing, water, soil, and air samples. The test is based on the inhibition of acetylcholinesterase by the organophosphoric group of the substances. In positive tests the indicator paper turns pink-to-violet and in negative tests it turns a yellow color.

Submitted on August 14, 1967






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Copyright © 1968 by the American Association for Clinical Chemistry.