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Clinical Chemistry 14: 391-402, 1968;
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Clinical Chemistry, Vol 14, 391-402, Copyright © 1968 by the American Association for Clinical Chemistry

Ultraviolet-absorbing Urinary Components of Mentally Retarded Children and Schizophrenic Adults

Adam W. Lis 1, Roman Bijan 1, Elaine W. Lis 1, and Konrad F. de Hackbeil 1

1 Nucleic Acids Laboratory, Department of Pathology, and Multiple Discipline Clinic, Crippled Children’s Division, University of Oregon Medical School, Portland, Ore. 97201; in cooperation with the Mental Health Division, Oregon Fairview Home, Salem, Ore., Dr. J. M. Pomeroy, Superintendent.

Urinary excretion of ultraviolet-light-absorbing end products of metabolism was studied in mentally retarded children and schizophrenic adults. Excretion of the major end product of pyrimidine metabolism, pseudouridine (5-ribosyluracil), and one of the catabolic derivatives of nicotinic acid, N-methyl-2-pyridone-5-carboxamide, were both found to be depressed in more than half the mentally retarded children and all the schizophrenic adults studied. In addition, a number of previously unidentified components have been found in both types of mental abnormality, as well as in control subjects, some of which components appear to be present in abnormal quantities.






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Copyright © 1968 by the American Association for Clinical Chemistry.