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Clinical Chemistry 14: 911-917, 1968;
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Clinical Chemistry, Vol 14, 911-917, Copyright © 1968 by the American Association for Clinical Chemistry

A Comparative Study of Three Methods Measuring Prothrombin Time

Algird V. Gudaitis 1 and Robert M. Donauer 1

1 Medical Laboratories of The Prudential Insurance Company of America, Newark, N. J. 07101.

A comparative study of the Fibrometer, Seratek, and manual technics measuring prothrombin time is described. Three technicians, 3 thromboplastin preparations, and 10 blood specimens with 10 replications were utilized in a 3 x 3 x 10 factorial design. It was found that the reproducibility of each method was subject to an interaction between technician, method, and reagent. In the hands of experienced technicians, the Seratek method was more frequently reproducible than the other two methods. This does not rule out the possibility of the Fibrometer being the method of choice with any particular technician or when less experienced technicians are performing prothrombin time measurements in rotation. The Fibrometer was found to produce the shortest prothrombin time. The importance of considering interaction in comparative or quality control studies consisting of several variables is emphasized.

Submitted on January 10, 1968
Accepted on February 5, 1968






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Copyright © 1968 by the American Association for Clinical Chemistry.