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Clinical Chemistry 15: 1011-1016, 1969;
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Clinical Chemistry, Vol 15, 1011-1016, Copyright © 1969 by the American Association for Clinical Chemistry

Two-Dimensional Paper Chromatographic Determination of Amino Acids in Urine

Carmine J. Spinella 1

1 Dept. of Pathology, Rhode Island Hospital, Providence, RI 02902.

In an attempt to screen children for amino-aciduria related to various inborn errors of metabolism, a two-dimensional paper chromatography method was developed. This method requires no expensive equipment, resolves a standard mixture of 17 agr-amino acids, is consistently reproducible, and requires less than 7 hr from start to visualization of the chromatogram.

Submitted on July 12, 1968
Accepted on February 3, 1969






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Copyright © 1969 by the American Association for Clinical Chemistry.