Clinical Chemistry AACC Online Job Center
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 15: 997-1001, 1969;
This Article
Right arrow Full Text (PDF)
Right arrow Submit an electronic Letter to
the Editor about this paper
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wilkins, J. W.
Right arrow Articles by Rivecca, J. N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wilkins, J. W., Jr.
Right arrow Articles by Rivecca, J. N.

Clinical Chemistry, Vol 15, 997-1001, Copyright © 1969 by the American Association for Clinical Chemistry

Measurement of Bisulfite in Biologic Solutions

James W. Wilkins Jr. 1 and James N. Rivecca 1

1 Department of Internal Medicine, University of Michigan, Ann Arbor, Mich 48104.

In order to evaluate the toxicity of sodium bisulfite (NaHSO3) used in peritoneal dialysis solutions it was necessary to measure bisulfite in simple solutions and serum. A microdiffusion technic is described for quantification of bisulfite. This involves evolution of SO2 gas from bisulfite by acidification, trapping it as H2SO3, oxidation of the H2SO3 to H2SO4 by hydrogen peroxide, and titration of the hydrogen ion with dilute base. The method is easily performed and is quantitative in the range of 50-500 µg bisulfite per milliliter in simple solutions. Studies in serum show incomplete yet quantitatively reproducible recovery.

Submitted on April 5, 1968
Accepted on March 19, 1969






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1969 by the American Association for Clinical Chemistry.