Clinical Chemistry
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Clinical Chemistry 15: 1124-1131, 1969;
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Clinical Chemistry, Vol 15, 1124-1131, Copyright © 1969 by the American Association for Clinical Chemistry

Nonspecificity of Urinary Lead Measurements by Atomic Absorption Spectroscopy

A Spectrophotometric Method for Correction

Robert J. Segal 1

1 Clinical Chemistry Laboratory, Department of Pathology, Hartford Hospital, Hartford, Conn 06115.

Lead measurements by direct AAS at 217 nm on a pooled urine sample gave values of 57 µg/l by the method of standard additions. In contrast, dithizone procedures gave values of 15-20 µg/l. Studies demonstrated that various urine salts and organic compounds contributed to the absorbance at 217 nm. These native urine materials also give a similar absorbance value at 220 nm, a line not related to lead emitted by the lead hollow cathode tube. Thus, correction of the nonlead absorbance was possible by subtracting the A220 from A217. Utilizing this correction, the standard addition procedure gave values of 12 µg/l. The correction technic was also applied to the lead isolation-concentration technic of Kopito and Shwachman (3) which employs bismuth coprecipitation. The simplicity of operations, increased sensitivity and reproducibility obtained by coupling the AAS correction technic with bismuth coprecipitation recommends it as a method for serious consideration.

Submitted on October 2, 1968
Accepted on March 14, 1969




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Copyright © 1969 by the American Association for Clinical Chemistry.