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Clinical Chemistry 15: 255-260, 1969;
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Clinical Chemistry, Vol 15, 255-260, Copyright © 1969 by the American Association for Clinical Chemistry

Thin-Layer Chromatography of Anticonvulsant Drugs

C. E. Pippenger 1, J. E. Scott 1, and H. W. Gillen 1

1 the Biochemical Research Laboratory of the New Castle State Hospital, New Castle, Ind., and the Department of Neurology, Indiana University School of Medicine, Indianapolis, Ind.

A rapid semiquantitative method for the determination of anticonvulsant drugs in blood and urine by thin-layer chromatography is described that is applicable in most laboratories. Utilization of SilicAR TLC-7GF with benzene:acetone (4:1), chloroform:acetone(9:1), and carbon tetrachloride:acetone(7:3) provides separation of Dilantin, phenobarbital, Mysoline, Phenylethylmalondiamide, Mesantoin, and Nirvanol.

Submitted on May 28, 1968
Accepted on August 15, 1968






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Copyright © 1969 by the American Association for Clinical Chemistry.