Clinical Chemistry AACC Online Job Center
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 15: 649-660, 1969;
This Article
Right arrow Full Text (PDF)
Right arrow Submit an electronic Letter to
the Editor about this paper
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Becker, W.
Right arrow Articles by Störiko, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Becker, W.
Right arrow Articles by Störiko, K.

Clinical Chemistry, Vol 15, 649-660, Copyright © 1969 by the American Association for Clinical Chemistry

Immunologic Determination of Proteins Found in Low Concentrations in Human Serum

W. Becker 1, H. G. Schwick 1, and K. Störiko 1

1 Behringwerke AG, Marburg/Lahn, Germany.

Of 42 well-characterized proteins of human blood plasma, 23 previously have been determined by quantitative immunochemical methods. Quantitative data on an additional 10 plasma proteins are now communicated. Antiserums against the following proteins have been prepared: agr1B-glycoprotein (easily precipitable agr1-glycoprotein). agr1T-glycoprotein (tryptophane-poor agr1-glycoprotein), agr1-antichymotrypsin (agr1X-glycoprotein), agr2-antithrombin (antithrombin III), Zn-agr2-glycoprotein, agr2-neuramino-glycoprotein (C'1 esterase inhibitor), beta2-glycoprotein II and III, ggrD-globulin.

These proteins were determined in normal human serums by applying radial immunodiffusion. Highly purified and physicochemically well-defined proteins were used as standards. Coagulation factor XIII (fibrin-stabilizing factor) was determined immunochemically in normal plasma using a specific antiserum. A genetically determined deficiency of beta2-glycoprotein I has been found in healthy individuals. As yet, no conclusions on the biologic function of this protein can be drawn from the results. The available data on physiologic function and pathophysiologic abnormalities of all proteins mentioned are discussed.

Submitted on November 2, 1968
Accepted on November 23, 1968






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1969 by the American Association for Clinical Chemistry.