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Clinical Chemistry 15: 720-726, 1969;
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Clinical Chemistry, Vol 15, 720-726, Copyright © 1969 by the American Association for Clinical Chemistry

Non-Urate Chromogens in Body Fluids

Wendell T. Caraway 1

1 Laboratories of McLaren General Hospital, 401 Ballenger Highway, Flint, Mich. 48502; St. Joseph Hospital, and the Flint Medical Laboratory, Flint, Mich.

Compounds which interfere in the analytic determination of uric acid are referred to as "non-urate chromogens." Ascorbic acid, when added to serum, causes a significant increase in apparent uric acid levels as determined by a carbonate-phosphotungstate method. The ratio of apparent urate to ascorbic acid is 1:3, a value in close agreement with that obtained for the ratio of labile non-urate chromogens to ascorbic acid in fresh plasma. Ascorbic acid, as well as most of the non-urate chromogens, can be eliminated by mild alkaline treatment prior to adding phosphotungstic acid. These results indicate that the major non-urate chromogen in the average serum is ascorbic acid. The nature of other non-urate chromogens in body fluids is reviewed.

Submitted on December 2, 1968
Accepted on January 5, 1969






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Copyright © 1969 by the American Association for Clinical Chemistry.