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Clinical Chemistry 16: 44-53, 1970;
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Clinical Chemistry, Vol 16, 44-53, Copyright © 1970 by the American Association for Clinical Chemistry

Evaluation of Serum Argininosuccinate Lyase (ASAL) Concentrations as an Index to Parenchymal Liver Disease

Rafael Z. Campanini 1, Rene A. Tapia 1, William Sarnat 1, and Samuel Natelson 1

1 Biochemistry Department, Michael Reese Hospital and Medical Center, Boston, Mass.

Serum concentrations of argininosuccinate lyase were determined in 122 patients with primary and secondary diseases of the liver. For comparison, patients with diseases involving other organs of the body were also studied. Extent of liver damage was evaluated by liver biopsy and in some cases, were assessed at autopsy. Daily assays, made during the course of the hospital stay, were correlated with blood concentrations of SGOT, SGPT, LDH, CPK, alkaline phosphatase, bilirubin, total and free cholesterol, and with the thymol turbidity and cephalin flocculation tests, and the albumin to globulin ratio. We tentatively conclude that, compared with these other commonly used tests of liver function, measurement of ASAL is a more specific and sensitive test for disease of the liver parenchyma. The procedure is simple and is readily made routine.

Submitted on May 6, 1969
Accepted on August 28, 1969




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