Clinical Chemistry
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Clinical Chemistry 16: 7-14, 1970;
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Clinical Chemistry, Vol 16, 7-14, Copyright © 1970 by the American Association for Clinical Chemistry

Blood Volume Changes during Three-Week Residence at High Altitude

L. G. Myhre 1, D. B. Dill 1, F. G. Hall 1, and D. K. Brown 1

1 Laboratory of Environmental Patho-Physiology, Desert Research Institute, Nevada Southern University, Boulder City, Nev. 89005; and the Department of Anatomy and Physiology, Indiana University, Bloomington, Ind. 47401.

Circulating red blood cell volumes were determined by the carbon monoxide method, and plasma volumes were calculated in four men 20, 29, 71, and 75 years old, and two women 29 years of age before, during, and after exposure to an altitude of 3800 m. In the four youngest subjects there were early increases in hemoglobin concentration during the first days at the stated altitude attributed to decreases in plasma volume. At the same time, hemoglobin concentration decreased and plasma volume increased in the oldest subject. Red cell volumes were slow to change, and it was concluded that 3 weeks or more of exposure to this altitude are required to affect significantly the red cell volume in man.

Submitted on August 9, 1969




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Copyright © 1970 by the American Association for Clinical Chemistry.