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Clinical Chemistry 16: 925-930, 1970;
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Clinical Chemistry, Vol 16, 925-930, Copyright © 1970 by the American Association for Clinical Chemistry

Prediction of Haptoglobin and agr2-Macroglobulin Concentrations from Electrophoretic Patterns of Serum agr2-Globulin

M. Henry Gault 1, Eleonore Elzer 1, and Alec Gabe 1

1 Department of Medical Chemistry, Queen Mary Veterans Hospital, 4565 Queen Mary Rd., Montreal 247, P.Q., Canada.

Cellulose—acetate electrophoretic densitometry patterns for agr2-globulin have been analyzed, with sera from 150 patients. The mobility of serum agr2-macroglobulin exceeds that of haptoglobin to the extent that certain patterns correlate with abnormal concentrations of one or both of these proteins in serum. The most readily recognizable patterns occur when there is a major increase in one protein and the other remains normal. A very low value for one protein, particularly haptoglobin, can also be recognized. Concentration of these two proteins can be roughly predicted under definable circumstances.


Key Words: cellulose acetate electrophoresis • immunodiffusion • densitometry • normal values • total agr2-globulin • screening applications

Submitted on July 2, 1970






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Copyright © 1970 by the American Association for Clinical Chemistry.