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Clinical Chemistry 16: 941-944, 1970;
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Clinical Chemistry, Vol 16, 941-944, Copyright © 1970 by the American Association for Clinical Chemistry

Variations in Blood ATP after Oral Administration of Glucose, in Individuals Diagnosed as Normal, Equivocal, or Diabetic According to the Glucose Tolerance Sum Principle

Rita M. Windisch 1, P. Robert Pax 1, and Mark M. Bracken 1

1 Chemistry Division, Department of Pathology, Mercy Hospital, Pittsburgh, Pa. 15219.

Blood adenosine triphosphate was determined for 35 individuals at various times after they had ingested glucose. They were divided into four groups, categorized according to the "glucose tolerance sum" principle as normal, equivocal, or abnormal. Patients showing glucose intolerance also had supranormal concentrations of ATP as compared to the fasting level. Data are presented which suggest that the increase in ATP is a regulatory mechanism for insulin secretion.


Key Words: diabetes • possible mechanism of effect on ATP

Submitted on July 27, 1970






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Copyright © 1970 by the American Association for Clinical Chemistry.