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Clinical Chemistry 16: 1012-1015, 1970;
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Clinical Chemistry, Vol 16, 1012-1015, Copyright © 1970 by the American Association for Clinical Chemistry

Variation in Urinary Creatinine Excretion and Its Relationship to Measurement of Urinary 17-Hydroxycorticosteroids

Philip E. Cryer 1 and Jonas Sode 1

1 Naval Medical Research Institute and Naval Hospital, Bethesda, Md. 20014.

Urinary creatinine excretion, measured in 96 24-h urine specimens collected from a single subject, was less variable (CV, 9.3%) than daily urine volume (CV, 20.7%). However, a small variation in measured creatinine excretion did exist, since the observed CV of 9.3% was not explicable either on the basis of analytical error (CV for replicate determinations, 1.1%) or of collection error. Thus, 24-h urinary creatinine excretion is not constant. On the other hand, demonstrated variation in creatinine excretion was small, and urinary 17-hydroxycorticosteroids could be validly expressed in mg/g of creatinine. In a given individual, biologic variation in 24-h creatinine excretion is negligible as compared with variation in 17-hydroxycorticosteroid excretion.


Key Words: diagnostic aid to distinguishing obesity and Cushing's syndrome

Submitted on July 22, 1970
Accepted on October 15, 1970






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Copyright © 1970 by the American Association for Clinical Chemistry.