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Clinical Chemistry 16: 1022-1027, 1970;
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Clinical Chemistry, Vol 16, 1022-1027, Copyright © 1970 by the American Association for Clinical Chemistry

Biological and Analytic Components of Variation in Long-Term Studies of Serum Constituents in Normal Subjects

II. Estimating Biological Components of Variation

Eugene K. Harris 1, Paul Kanofsky 1, George Shakarji 1, and Ernest Cotlove 1

1 Laboratory of Applied Studies, Division of Computer Research and Technology (E.K.H., G.S.), Biometry Branch, National Cancer Institute (P.K.), and the Clinical Pathology Department (E.C.), National Institutes of Health, Bethesda, Md. 20014.

Standard statistical analysis of variance has been used on data from weekly determinations of 15 blood constituents in each of 68 normal subjects, our purpose being to isolate and estimate biological components of observed variation. These components include intra-individual, or "personal" variation, and inter-individual, or "group" variation. The most critical problem, that of separating personal variation from long-term analytic deviations in each individual's data record, was resolved with the aid of concurrent analysis of a constant "pooled" serum. Comparison of isolated personal variation with inter-individual variation indicates that many common blood tests—e.g., magnesium, calcium, total protein, uric acid, serum enzymes, and cholesterol—could contribute to an individually distinctive blood "profile" if substantial improvements were made in analytic precision. Presently, only cholesterol (among older women) and uric acid (in males) appear to possess strong capabilities for distinguishing among normal individuals.


Key Words: statistical analysis of variance in clinical chemistry • "profile" from multiphasic screening • inter- and intra-individual variation • normal values




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