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Clinical Chemistry 16: 335-338, 1970;
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Clinical Chemistry, Vol 16, 335-338, Copyright © 1970 by the American Association for Clinical Chemistry

A Method for Determining Nitrofurantoin in Urine in the Presence of Phenazopyridine Hydrochloride and Its Metabolites

R. D. Hollifield 1 and John D. Conklin 1

1 Norwich Pharmacal Company, Norwich, N.Y. 13815.

The high urinary drug concentrations usually encountered after administering nitrofurantoin in the chemotherapy of urinary tract infections are often measured by the nitromethane—Hyamine method. We show here that, if the urinary tract analgesic, phenazopyridine hydrochloride, and its related metabolite(s) are in the urine, they interfere with this determination of nitrofurantoin. Nevertheless, the nitromethane—Hyamine method may be modified to determine nitrofurantoin quantitatively in urine collected from human subjects who have been treated with the analgesic and nitrofurantoin concomitantly.

Submitted on February 25, 1969
Accepted on July 17, 1969






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Copyright © 1970 by the American Association for Clinical Chemistry.