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Clinical Chemistry 16: 352-353, 1970;
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Clinical Chemistry, Vol 16, 352-353, Copyright © 1970 by the American Association for Clinical Chemistry

A Cause of Apparently Abnormal Urinary 17-Hydroxy Corticosteroids Responses to Metyrapone in Normal Subjects

William Jubiz 1, Jacqueline Frailey 1, and Frank H. Tyler 1

1 Department of Medicine and the Laboratory for the Study of Hereditary and Metabolic Disorders, University of Utah College of Medicine, Salt Lake City, Utah 84112.

The metyrapone test is used to evaluate adrenal and pituitary disorders. The response to metyrapone administration can be erroneously interpreted as negative if a method that includes benzene— water partition is used to measure urinary 17-hydroxy corticosteroids. The reason for this is that benzene—water partition excludes most of the tetrahydrodeoxycortisol from the final extract, although this is the urinary steroid metabolite that increases after metyrapone administration.

Submitted on June 26, 1969
Accepted on July 15, 1969






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Copyright © 1970 by the American Association for Clinical Chemistry.