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Clinical Chemistry 16: 486-494, 1970;
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Clinical Chemistry, Vol 16, 486-494, Copyright © 1970 by the American Association for Clinical Chemistry

Plasma Fibrinogen: Determination, Normal Values, Physiopathologic Shifts, and Fluctuations

George F. Grannis 1

1 Division of Clinical Chemistry, Department of Pathology, Ohio State University, 410 W. 10th Ave., Columbus, Ohio 43210.

The determination of plasma fibrinogen, either as clottable protein or protein precipitable with glycine or ammonium sulfate, is evaluated in terms of principles of analysis, analytic error, normal and abnormal ranges, physiologic stability, and pathologic variability of fibrinogen concentration. The quantitative comparison of analytic error, population ranges, and individual variability should permit more precise interpretation of clinical data than previously has been possible.


Key Words: clottable protein • thrombin • fibrin • ultraviolet absorption, 282 nm • glycine precipitant • ammonium sulfate precipitant • turbidimetry • intraindividual constancy • pregnancy and plasma fibrinogen • diabetes • vascular and blood-clotting diseases • arthritis • liver disease • blood clotting • normal values • homeostasis

Submitted on February 6, 1970
Accepted on March 6, 1970




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Copyright © 1970 by the American Association for Clinical Chemistry.