Clinical Chemistry
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Clinical Chemistry 16: 507-511, 1970;
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Clinical Chemistry, Vol 16, 507-511, Copyright © 1970 by the American Association for Clinical Chemistry

Phenotyping of Hyperlipoproteinemias

Effect on Electrophoretic Pattern of Serum Storage at Ambient, Refrigerator, or Freezing Temperatures

James Winkelman 1, Donald R. Wybenga 1, and Frank A. Ibbott 1

1 Bio-Science Laboratories, 7600 Tyrone Ave., Van Nuys, Calif. 91405.

The stability of serum specimens collected for cellulose acetate electrophoresis of lipoproteins has been studied for each of the hyperlipoproteinemia phenotypes. In general, samples kept at room temperature for three days are still suitable for analysis. On longer standing, artifacts can cause misinterpretation of strips, or render them completely unreadable. If specimens are stored at refrigerator or freezer temperatures, deterioration is retarded but the period of stability after they are returned to room temperature is unaltered. A second freeze-thaw cycle makes specimens unsuitable for analysis. Samples can be stored at refrigerator temperatures for at least 28 days and at freezer temperatures for at least 14 days if one freeze-thaw cycle is used.


Key Words: freeze-thawing of serum • lipoprotein denaturation • cellulose acetate electrophoresis

Submitted on February 16, 1970
Accepted on April 3, 1970






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Copyright © 1970 by the American Association for Clinical Chemistry.