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Clinical Chemistry 16: 562-565, 1970;
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Clinical Chemistry, Vol 16, 562-565, Copyright © 1970 by the American Association for Clinical Chemistry

Normal Concentrations of Lactate, Glucose, and Protein in Cerebrospinal Fluid, and the Diagnostic Implications of Abnormal Concentrations

J. D. Pryce 1, P. W. Gant 1, and K. J. Saul 1

1 Pathology Department, Anglesea Road Wing, Ipswich and East Suffolk Hospital, Anglesea Rd., Ipswich, England.

Normal values for glucose, lactate, and protein in cerebrospinal fluid have been established and the relationships among them studied. Normal protein concentration is related to age. Glucose and lactate values are correlated with each other and with sex and age. By the technique of pattern appreciation, these estimations provide a useful confirmatory test for cerebrovascular accidents and for differentiating intracranial hemorrhage from other types of accident and from bloody spinal fluid taps, and they have considerable prognostic value in assessing the milder cases. They also have a restricted value in certain other conditions.


Key Words: sex- and age-related effects • cerebrovascular accidents, diagnosis • intracranial hemorrhage • prognostic aid • nephelometry of protein • "pattern appreciation," statistical analysis • statistical extraction of a "normal" population • neurological diseases

Submitted on November 26, 1969
Accepted on April 17, 1970






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Copyright © 1970 by the American Association for Clinical Chemistry.