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Clinical Chemistry 16: 633-636, 1970;
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Clinical Chemistry, Vol 16, 633-636, Copyright © 1970 by the American Association for Clinical Chemistry

Diagnostic Application of Metabolic Studies with Isotopes

Ferenc Hutterer 1, Laszlo Sarkozi 1, John Roboz 1, and Paolo Bacchin 1

1 Department of Chemistry, The Mount Sinai Hospital, New York, N. Y. 10029.

The mechanism of the maintenance of normoglycemia in chloroform intoxication in rats was studied with isotopes. Metabolic pathways were altered before the concentration of blood glucose changed significantly. Measurement of the incorporation of precursors rather than the determination of the concentration of the metabolic end products (e.g., glucose) may provide more diagnostic information and may more sensitively detect early diseases or disease stages.


Key Words: CCl4 intoxication • precursor incorporation • mass health screening • mass spectrometry • gluconeogenesis from 14C-labeled pyruvate and glycerol • rats • AutoAnalyzer






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